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Tuesday 19 March 2013

Human functional health in nutrition and metabolism


1.      Introduction

Nutrition is a process whereby food is taken into the body and broken down, allowing for a production in energy, necessary for all living cells to maintain their structure and function (Field & Smith, 2008). A balanced nutritional status consists of a diet comprised of carbohydrates, proteins, fats, vitamins and mineral. An excess, or deficiency, in these essential components can lead to poor nutritional status and in some cases malnutrition.

Nutritional process means processes involved in nutrient intake and use which together influence the nutritional status of a person (Fuller & Shcaller, 2000). Beside ingestion, digestion, absorption and transport, metabolism is also one and the final process in the nutritional processes.  

Metabolism consists of processes that produce and use the energy within body cells.  Thus this complex process starts as the cell is fueled by nutrients.  Hence, to achieve an optimal health, energy used must be matched with energy production.  Generally, energy is used in two major ways; firstly to maintain essential life processes such as breathing, nervous system function and blood circulation.  Secondly, to support nonessential life activities such as running, working, thinking and dealing with stress.  In addition to those, some of the energy is also being used for nutritional processes like digestion and absorption

2.      Importance of Nutrition and metabolism

Good nutrition, an adequate and well balanced diet is a cornerstone of good health (World Health Organization, 2012). Poor nutrition can lead to reduced immunity, increased susceptibility to disease, impaired physical and mental development, and reduced productivity. Nutrients preserve health and ensure proper growth and development, with longlasting effects on immunity, cognition, and behavior (2011).

Therefore, adequate nutrition is necessary to build up immunity against diseases, and prevent the diseases caused by certain nutritional deficiencies.

Nutritional care of patients is a primary responsibility of nurses, and is essential to maintaining optimum health, preventing complications, and improving wound healing. A poor nutritional status can lead to malnutrition, which can have serious impacts on individual’s quality of life (Field and Smith, 2008). Therefore, nurses need to perform nutritional assessment to identify nutritional risks, and to provide interventions fulfilling the nutritional needs of the individual patient.

Metabolism  composed of anabolism and catabolism hence, refers to the highly integrated network of chemical reactions, such as growth, generation of energy, elimination of wastes, and other bodily functions as they relate to the distribution of nutrients in the blood after digestion and living cells growth and sustaining (Dillon, 2007).

Based on (Krapp, 2002), anabolic and catabolic networks have three major functions including  to extract energy from nutrients, to synthesize the building blocks that make up the large molecules of life such as proteins, fats, carbohydrates, nucleic acids, and combinations of these substances, then finally synthesize and degrade molecules require for special functions in the cell; These reactions are controlled by enzymes, protein catalysts that increase the speed of chemical reactions in the cell without themselves being changed.

The importance role of metabolic pathways in human health is to supply the body with the energy and nutrients it needs for maintenance of body functions, growth, tissue repair, and other processes (Fuller & Schaller-Ayers, 2000).


3.      Assessment of Nutrition and Metabolism

Assessment of nutrition involves collecting and interpreting data to identify healthy nutritional practices, nutrition risks, altered nutrition status, and the effects of altered nutrition (Fuller & Schaller-Ayers, 2000). Data collection is performed by interview, diagnostics studies, anthropometric measurement and physical examination.

3.1.History taking and interview:

Interview enquiring about body weight such as recent weight changes is important. Unintentional weight loss may indicate serious nutrition and health problem, and sudden weight gain may indicate fluid retention, electrolyte imbalance and medication side effect. Interview about eating habits, food preference and dislike, food allergies is required to probe nutritional problems and risks which contribute to negative health outcome.

The nutritional history of clients experiencing alterations in nutrition and metabolism is of critical importance in the development of the plan of care. Several methods can be used in collecting these subjective data namely: 24-hour recall, food frequency questionnaire, food record, and diet history; The 24-hour recall requires client identification of everything consumed in the previous 24 hours. Family members can often assist with these data, if necessary. The food-frequency method gathers data relative to the number of times per day, week, or month the client eats particular foods and helps to validate the accuracy of the 24- hour recall and provides a more complete picture of foods consumed. The food record provides quantitative information regarding all foods consumed, with portions weighed and measured for three consecutive days which requires full client or family member cooperation. The diet history elicits detailed information regarding the client’s nutritional status, general health pattern, socioeconomic status, and cultural factors.

Assessment of nutritional knowledge is necessarily important to identify misconceptions about nutrition and learning needs for nutrition. Nutritional knowledge involves asking patient about food groups on the pyramid, foods high in calories, foods with limited nutritional value, foods high and low cholesterol, and ability to interpret food labels.

Interview about socioeconomic background such as income, education level and mealtime setting; eating at home with family or outside, are important because these factors are affecting patients’ nutritional status. Patient’s medical history is important information to determine nutritional risks. Medication history is also important that some drugs alter nutritional and metabolic states.

3.2.Diagnostic study:

When assessing nutritional status, laboratory results are reviewed to; screen the patient for nutritional problems, quantify the extent of protein-calorie malnutrition, and indentify specific deficiencies in essential nutrients (Fuller, 2000). Blood albumin level is monitored to determine the risk of protein-calorie malnutrition. Albumin, transferrin, and lymphocytes are serum protein; decreased serum levels indicate protein deficiencies (Fuller, 2000). Nitrogen balance is evaluated; positive nitrogen balance (+2 to +4) indicates optimal nutritional status.

Haemoglobin, haematocrit, and transfferin level are monitored to screen out iron deficiency anemia. Serum potassium and sodium level are monitored to determined deficiency or excess. Calcium and phosphate levels are measured for the patients who have potential risk of mineral bone disorders. Cholesterol and lipid values are checked up for the people with risk of cardiovascular disease.

3.3.Anthropometric assessment:

Anthropometric measurement includes height, weight, skinfold thickness, and various body circumferences. Body mass index (BMI) is calculated to determine normal weight, overweigh or obesity.  

Midarm circumference (MAC) is measured to determine the muscle mass and fat; MAC decreases with under-nutrition and increases with obesity and muscle hypertrophy. Tricep skinfold (TSF) is measured to determine total body fat.

3.4.Physical assessment:

General survey includes appearance of overweight of underweight, signs of muscle wasting and patterns of fat distribution. Examination of integumentary system involves skin; dry or flakiness, hair; dry, thin sparse, or easily plucked, and nails; brittle, pale, spoon-shaped or transverse ridges across the nail plate, which are signs of malnutrition.

Examination of oral cavity is important to determine presence of infection or inflammation of gum and oral mucosa, which hinder food intake.  Oral cavity examination involves; lips for puffy, swollen, fissure at the corner of the mouth and cheilosis, tongue for pale or lesion, oral mucosa for swollen, dryness or redness, and teeth for mottled, cavities of poor dentition. Missing or decayed teeth of ill-fitting dentures lead to reduced food intake (Posthauer, 2012).

4.      Challenges and issues related to nutrition and metabolism

According to Park et al. (2011) nurses who have direct interactions with patients during hospitalization are in a good position to inform those who are at risk of nutritional problems and metabolic diseases, and counsel them on scientific and practical dietary therapies. There are some challenges to fulfil nutrition and metabolic needs of the patients.

4.1. Knowledge and competency

 The level of nutritional knowledge will influence nurses’ attitude and practice to provision of nutritional care for the patients (Fletcher & Carey, 2011).  Warber et al. (2000) and Schaller & James (2005) reported that nurses have  suboptimal level of nutritional knowledge in Western countries.  Fletcher  & Carey (2011) also highlighted that inadequate nutritiona knowledge a key factor for inconsistancies in nutritional screening. They recommended, developing nutritional teams and the provision of further education as solutions to reduce the nutritional problems.

4.2. Identification of nutritional problem

 There is only a minor group of patient at risk of nutrition are identified (Mowe et al., 2006). Malnutrition remains undetected in common clinical practice, which contributes to prolong hospital stays and negative health outcomes. It is recommended that nutritional risk screening should be undertaken on admission, and specific nutritional counseling should be undertaken when the significant risk is detected.

4.3. Nutritional intervention related to psycho-social factors

Psychological factors; depression, anxiety and stress, and socioeconomic factors; income, education, lifestyles, and family supports, all contribute to either healthy eating of poor eating habits. The study done by (Mead, Gittelsohn, De Roose, & Sharma (2010) showed that food knowledge, self-efficacy and healthy food intensions are associated with dietary behavior. Therefore, they recommended that nutritional intervention should be target to behavioral changes strategies.

4.4. Nutritional issues related to vulnerable groups

Promoting proper nutrition in infant and young children is the most important nutritional intervention. World Health Organization (2012) reported that malnutrition counted two third of death in children under five.  Nutrition and nurturing during the first years of life are both crucial for life-long health and well-being. Infant and young children may have inborn errors of metabolism are: galactosemia, phenylketonuria, lactose intolerance, and maple syrup urine disease (Fuller & Schaller-Ayers, 2000).. Nurses have an important role in diagnosing metabolic disorders which requires a physical examination and blood tests and then the diet modifications needed for each disease.

Adolescents are exposed to undernutrition, micronutrient malnutrition as well as obesity. Their lifestyle and eating behaviours, along with underlying psychosocial factors, are particularly important threats to adequate nutrition.  Inadequate nutrition in adolescence can potentially retard growth and sexual maturation. Therefore, nutritional education should be given effectively for this target group.

Women with pregnancy and breastfeeding are a target population who need special nutritional support. The consequences of poor nutritional status in women during pregnancy directly affect women’s health status, and impacts on birth weight and early childhood development (WHO, 2012). Maternal health and nutrition before and during pregnancy, and early infant nutrition may be important in the prevention of non-communicable diseases throughout the life course.

Elderly people are also vulnerable to nutritional risk. World Health Organization stated that many of the diseases suffered by older persons are the result of dietary factors. These factors are then compounded by changes that naturally occur with the ageing process; changes nutritional process and metabolism. Dietary changes seem to reduce risk-factor in older people (WHO, 2012). For instance, reductions in saturated fat and salt intake would reduce blood pressure and cholesterol concentrations, reducing the burden of cardiovascular disease.

4.5.Nutritional Challenges in chronic diseases

Patients with chronic diseases such as heart failure, coronary artery disease, chronic obstructive pulmonary disease (COPD), hepatic cirrhosis, rheumatoid arthritis, end-stage kidney disease, human immunodeficiency virus (HIV) infection, diabetes, etc. will require integrated health care programs to maintain functional autonomy and quality of life. These adjuvant interventions are mainly based on nutritional support and exercise programs (Biolo, Guadagni, & Ciocchi, 2011).

The overall goal of nutrition intervention in diabetes is to achieve and maintain optimal metabolic outcomes with respect to glucose and lipid levels. Dietary recommendations for people with diabetes do not differ significantly from those for the general population. However, carbohydrate intake is a dietary focus because it has a greater impact on postprandial glucose levels than protein and fat intake. The postprandial glycemic response to carbohydrate is affected by both the amount and the type of carbohydrate consumed. Whole-grain carbohydrates, for instance, produce a lower and slower glycemic response than processed carbohydrates (Mann et al., 2004).

Among people with chronic kidney diseases, reduced dietary intake or malnutrition related to anorexia, nausea and vomiting, changes in taste and smell, and dietary restrictions. Also implicated are heightened catabolism and metabolism, which increase as the disease progresses. Inflammation is linked to the increased energy expenditure seen in CKD. Because kidney function is inadequate, metabolic abnormalities appear, including anemia, acidemia, high blood levels of potassium, and disruption of the calcium-vitamin D metabolic pathway. Nutrition intervention for patients with CKD must consider their disease stage, nutritional status, metabolic abnormalities, and for patients with ESRD, type of dialysis (Mann, et al., 2004).

4.6.Nutritional Challenges in palliative care

Weight loss in cancer patients is associated with several serious complications including increased toxicity of chemotherapy, decreased response to therapy, increased morbidity such as infection, increased hospital LOS, decreased quality of life and increased mortality (Biolo, et al., 2011). In advanced cancer, anorexia and cachexia and malnutrition are highly prevalent. Nutrition support with an energy and protein dense nutritional supplement as a part of overall care, has been shown to reduce complications such as infection and length of hospital stay, promote weight gain, help build lean body mass, improves immune function, enhances quality of life, and increase strength and physical activity level in those who gained weight (Gaertner et al., 2012).
5.      Conclusion

Health assessment is central to nursing practice, and nutritional and metabolic assessment is very important which nurses are often omitted to perform. Since nutrition and metabolism is influenced by internal and external factors, identification of these factors is critical to rectify the nutritional risk and problem. Therefore, nurses are required to be knowledgeable and skilful in history-taking, physical examination, diagnostic measures, to determine potential or actual nutritional and metabolic problems. Upon identification of problems and issues collaborative actions with other professional, scientific researches with interventional study are required to address these issues.

6.      References:













 

 

Saturday 16 March 2013

Association of DepressionWith Malnutrition in Chronic Hemodialysis Patients

Author: Ja-Ryong Koo, Jong-Woo Yoon, Seong-Gyun Kim, Young-Ki Lee, Kook-Hwan Oh, Gheun-Ho Kim, Hyung-Jik Kim, Dong-Wan Chae, Jung-Woo Noh, Sang-Kyu Lee, and Bong-Ki Son

Journal: American Journal of Kidney Disease, Vol 41. No 5
Date of publication: May 2003


Introduction:
Depression is the most common psychological complication which increases mortality in chronic hemodialysis patients (Khalil, & Frazier, 2010). Depression is believed to be associated with poor oral intake leading to cause malnutrition. It is also believed that depression is associated with activation of proinflammatory cytokines which increase protein metabolism and cause protein energy malnutrition (Khalil, & Frazier, 2010).

This paper is reviewed to gain insight about the impact of depression on nutritional status in chronic hemodialysis patients.This study on association of depression with malnutrition in chronic hemodialysis patients was conducted at the outpatient hemodialysis unit of Hallym University Hospital, Chounchon, Korea.

 Purpose of the study:
The purpose of this study is to investigate the relation between depression and nutritional status in hemodialysis patients. This research article provides the important information that depression is closely related to nutritional status, and it could be independent risk factors for malnutrition.

 Method:
Study design is cross-sectional study. The participants are patients with chronic renal failure taking dialysis treatment more than 6 months who were free of acute illness with 3 months and not taking steroid therapy. There are total sixty-two patients participated in this study.

All patients were administered a Beck Depression Inventory (BDI) questionnaire, which include 21 items self-report rating, four point Likert scale measuring characteristic attitudes and symptoms of depression. From these 21 items 15 items accounted to thoughts feelings related to depression were selected to form Cognitive Depression Index (CDI).

Overall protein-energy nutritional status of the patients under study had been evaluated by using modified Subjective Global Assessment (SGA). The SGA includes four items scored on seven-point Likert scale, which items are weight loss during the past six months, anorexia, subcutaneous fat, and muscle mass. For anthropometric measurements, body mass index and midarm circumference were evaluated.  Dialysis adequacy and biochemical analyses were included for intact parathyroid hormone (iPTH), urea, albumin, hematocrit and urea.

 Statistical analysis:
Analysis of data is valid. Data are presented as mean and standard deviation. Correlations between variables were assessed using Pearson’s Correlation coefficients to assess the correlation between variables. Stepwise multiple regression analysis was perform to determine the association of BDI and CDI scores, Kt/V urea , duration of maintenance hemodialysis, sex, age, hematocrit and plasma bicarbonate level with nutritional parameters. Differences between groups were assessed using unpaired Student’s t-test and chi-square test. P less than 0.05 is considered significant.

Findings:
The result showed that 56.5% (n=35) of the participants had BDI above 21, the cut of score for the diagnosis of depression for Korean population. There was a significant positive correlation between severity of depressive symptoms and degree of malnutrition among hemodialysis patients.
There was a significant correlation between age and severity of depression and diabetic patients has higher BDI and CDI scores compared to non-diabetics patients. Both BDI and CDI scores are negatively associated with nutritional parameters, while these score did not correlate with BUN, plasma bicarbonate level and iPTH. This study also could rule out the high incidence of depression among hemodialysis patients that 34 out of 62 patients (54.8%) had major depressive disorders.


 Strengths and limitations:
This study has shown strong evidence for the positive association between depression and malnutrition in hemodialysis patients. This study had provided clear and valid conclusion that depression is closely related to nutritional status, which could be independent risk factors for malnutrition in chronic hemodialysis patients.

In terms of validity, depression is measured by Beck Depression Inventory (BDI) questionnaires, which is well-validated index of depression and correlated well with diagnostic criteria. According to the authors, BDI questionnaires are frequently used to assess depression in patients with ESRD. The 21 items in BDI are answered on four Likert scale in which 0 represents the absence of problem and 3 represents extreme problem, with total score range of 0-63.

Level of depression is classified as normal score, 5-9; mild to moderate depression, 10-18, moderate and severe depression, 19-29, and severe depression, 30-60. BDI score more than 18, classified as moderate to severe depression, were referred to an independent psychiatrist for clinical interview to confirm the diagnosis depression using DSM-IV criteria.

To control for the possible confounding contribution of somatic symptoms of physical illness and/or treatment effects to the physical symptoms of depression, a subset of 15 cognitive depression items from the total 21 items of the BDI were selected to form a Cognitive Depression Index (CDI). Using the CDI, cognitive beliefs (15 questions regarding thoughts and feelings related to depression) could be distinguished from somatic symptoms (6 questions related to physical symptoms associated with depression).

This study has some limitations with small sample size. There also has diagnostic dilemma for depression; important somatic symptoms for diagnosis of depression such as fatigue, anorexia, and sleep and bowel disorders could be due to uremia. Therefore, it is not clear for generalizibility of the finding.

 Nursing implication:
According to this study finding, nephrology nurses and clinicians are to give serious attention to psychological well beings of hemodialysis patients which have high impact on nutritional status as well as overall patient outcomes.

 In hemodialysis patients, depressive symptoms lead to poor clinical outcomes by biological and behavioural pathway (Khalil, Lennie, & Frazier, 2010). In biological pathway, depressive symptoms produced serious consequences related to nutritional status and cardiovascular risk. Behavioural pathway is related to the effect of depression on adherent to fluid and diet restriction, hemodialysis attendance and medication. Review of quantitative research evidence also showed that depressive symptoms are dietary non adherent in patients with end stage renal failure (Khalil & Frazier, 2010). Biological pathway could be treated with antidepressants, and adherent behaviours can be improved by cognitive behavioural therapy, exercise, positive thinking and individually targeted educational program (Khalil, et al., 2010).

Study conducted by Rahimi, Ahmadi & Gholyaf (2008) showed that application of Continuous Care Model made significant differences in level of depression, anxiety and stress in hemodialysis patients. Therapeutic use of self and emotional support is essential practice in daily care of the patients. Counselling services and appropriate referral are important intervention for hemodialysis patients with moderate and severe depression.

Conclusion:
This study gives important insight for the association between depression and malnutrition. Conducting this research has discovered a high incidence of depression among hemodialysis patients. This paper, is therefore, very useful to recognize that major attention is needed to address with integrated psychological interventions for hemodialysis patients.

Knowing that depression contributes to malnutrition among chronic hemodialysis patients, integrated psychological interventions could be designed to combat the problem of depression, thus patients’ nutritional and general health outcomes can be improved.

Further research with larger sample size is required to generalize the finding of association between psychological factors and patient outcomes. Based on the study evidence, interventional trials for depression and other psychological problems are recommended to study.


References: